Effect Of The Physical And Pharmacological Factors On Antioxidant Protection In Animals With Erosive-ulcerative Pathology Of The Gastroduodenal Area (tissue Specificity)
Abstract
L. Ponomarenko, O. Lykholat, O. Khomenko
Influence of the natural magnetic field (MP) is an integral part of the existence of all living systems on Earth. Artificial MPS appeared precisely due to human activity. It is established that the interaction of MP with biosystems, its biological activity depends on the biotropic parameters of this field, such as frequency, intensity, gradient (rate of growth), vector, pulse shape, exposure time and localization of influence. There is now no single point of view regarding the mechanisms of interaction of the MP with biological objects. Experimental investigations have documented the influence of MP on the reactions occurring in the free radical type. Free radical pathologies include diseases such as gastroesophageal reflux disease and peptic ulcer disease. Therefore, the search for factors that can affect the components of the system of oxidative homeostasis remains. The purpose of the work is to evaluate the isolated effect of the magnetic field and in combination with injections of L-arginine-L-glutamate into lipoperoxidation processes and antioxidant defense system in rat tissues with experimental pathology of the gastroduodenal zone. The modeling of erosive-ulcerative lesions of the gastroduodenal zone in rats was accompanied by an imbalance in the functioning of antioxidant defense systems and the intensification of lipoeroxidation LPO processes in the blood, liver, brain and stomach tissues of experimental animals. Applications of a magnetic field to animals with simulated pathology of the gastroduodenal zone resulted in inhibition of the processes of LPO in the blood of experimental rats at the activation of free radical reactions in the liver, brain and stomach tissues, on the background of partial decontamination of the glutathione system enzymes against the backdrop of an increase in the amount of reduced glutathione. With the combined action of glutargin and magnetic field in the blood, liver and brain tissues of experimental rats with erosive-ulcerative defeat of the gastroduodenal zone, activation of anti-radical, anti-peroxide protection enzymes, increased levels of reduced glutathione against the inhibition of glutathione reductase activity and a decrease in the intensity of the LPO processes with simultaneous normalization of processes of lipoperoxidation in the stomach tissue took place.
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