Analgesic effectiveness of new nanosilver drug
Abstract
A. M. Kovalenko, A. V. Tkachev*, O. L. Tkacheva, B. V. Gutyj, O. I. Prystupa, M. D. Kukhtyn, V. R. Dutka, Ye. M. Veres, O. O. Dashkovskyy, V. V. Senechyn, M. B.Riy and V. A. Kotelevych
The article provides data on the study of antimicrobial activity and analgesic efficacy of the medicine Mastitnano-BelGAU, which includes silver nanoparticles, copper nanoparticles, arginine, dexpanthenol, and distilled water. Based on the study of antimicrobial activity of the drug Mastitnano-BelGAU it was defined higher antimicrobial activity against clinical polyresistant strains of the genus Staphylococcus at a concentration of 104 cell/mL of samples 1 and 2, where respectively the concentration of the active substance of silver nanoparticles was 0.15 and 0.12 mg/mL. The tested samples of the remedy Mastitnano-BelGAU were characterized by higher antibacterial properties against the clinical strain R. aeruginosa 185, in contrast to the strain of Е. соlі 197. In the study of analgesic activity of the drug Mastitnano-BelGAU, it was found that it exhibits a significant long-term (within four hours) analgesic effect on the model of the pathogenic process induced by carrageenan. The most pronounced changes in pain sensitivity were recorded 60-120 min after the application of Mastnitano-BelGAU.
Keywords: Mastitnano-BelGAU; Dexpanthenol; Antimicrobial and analgesic activity; Mastitis; Cattle
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